Chat & E-mail
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Adium
Multi-protocol instant messaging client
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AdiumBook
Sync Adium IM & Address Book contacts
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aMSN
aMSN is a free open source MSN Messenger clone, with many features
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Chax
Chax is a collection of minor modifications and additions that make using Apple's iChat more enjoyable.
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Gabble
Yammer desktop client designed specifically for the world’s best operating system. Let Windows users wrestle with that crazy Adobe Air stuff. For Mac users there’s now a better way.
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Herald
Herald is a notification plugin for Mail.app, Apple's Mac OS X email client.
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Mail.appetizer
Incoming e-mail at a glance.
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Mozilla Thunderbird
Makes emailing safer, faster, and easier than ever before with the industry’s best implementations of features such as intelligent spam filters, built-in RSS reader, quick search, and much more.
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Picture Finder
Will use the email addresses in your Address Book and attempt to find the Gravatar for the associated email address. You can have it make up Identicons, Wavatars or MonsterIDs from the Gravatar web site. Also, if you’re feeling really nerdy, you can have it generate QR Codes for each email address, thanks to Google Code. For all those people in your address book who don’t have email addresses, it will attempt to make a really simple image using the first letter of the first and last names.
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Syrinx
Syrinx is a fully customizable twitter client designed for OS X 10.5+. Syrinx is built from two ideals: efficient workflow and customization.